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5 Mechanisms by which metformin acts through regulation of the gut microbiota 5.1 Acts by stabilizing the mucosal barrier of the GI tract The GI mucosal barrier with important physiological roles is a three-dimensional protective structure consisting of mechanical, chemical, immune and biological barriers

Users may experience: Nausea and vomiting Stomach cramps or abdominal pain Diarrhea or loose stools Heartburn or acid reflux Other Reported Side Effects Beyond digestive symptoms, some individuals report additional effects when taking acetyl-L-carnitine

Diabetes Care 2024 ;47(Suppl 1):S158-S178